RESEARCH PROFILE
Synthesis, structural and spectroscopic characteristics of multinuclear titanium(IV)-oxo complexes and their use in the production of polymeric-inorganic composite materials with photocatalytic and antimicrobial properties.
Synthesis and characterization of biodegradable iron-based materials and their application to the construction of stents used in cardiology and vascular surgery, and also scaffolds for biodegradable implants used in orthopedics.
Research on the modification of biological and mechanical properties of materials based on titanium dioxide and evaluation of their photocatalytic and biological activity and their application as biomedical materials.
Research on the use of vapor deposition techniques (CVD, ALD) of metallic nanolayers and metal oxides for surface modification of produced biomaterials in order to improve their mechanical and biological properties.
Manufacturing of titanium dioxide nanocoatings and their modification with platinum (II) complexes, and studies of the kinetics and mechanism of ligand substitution reactions in platinum (II) complexes.
Investigations on the use of metallic and non-metallic nanolayers in modern analytical methods.
Biomedical and bioinorganic chemistry of metal compounds (metal complexes in anticancer therapy, interaction of inorganic anticancer drugs with DNA), photochemistry and photophysics of coordination compounds (application of light for activation of metallodrugs), kinetics and reaction mechanisms.
Synthesis, structure, spectroscopy and magnetism of heterometallic transition metal complexes with carboxylate and thiocyanate bridges. Spontaneous resolution and chirality of trisoxalate chromium(III) and iron(III) complexes. EPR spectroscopy of radicals and transition metal ions.
GROUP MEMBERS
DSc.Piotr Piszczek, prof. NCU,
email: piszczek@umk.pl, phone: +48 (56) 611 45 92
DSc. Aleksandra Radtke, prof. NCU,
email: aradtke@umk.pl, phone: +48 (56) 611 43 16
DSc. Joanna Wiśniewska, prof. NCU,
email: wisnia@chem.umk.pl, phone: +48 (56) 611 49 73
DSc. Grzegorz Wrzeszcz, prof. NCU,
email: wrzeszcz@umk.pl, phone: +48 (56) 611 49 74
Dr Tadeusz Muzioł,
email: tmuziol@chem.umk.pl, phone: +48 (56) 611 49 76
Dr Adrian Topolski,
email: topolski@umk.pl, phone: +48 (56) 611 22 48
PROJECTS, GRANTS
COST Projects (NAMABIO, NEWGEN, HERALD and BIONECA)
DSc. Aleksandra Radtke, prof. NCU, DSc. Piotr Piszczek, prof. NCU
NCN Preludium Bis
DSc. Aleksandra Radtke, prof. NCU
Iron-based biodegradable materials – research on the relationship between the chemical structure and surface morphology of systems and their mechanical properties, susceptibility to corrosion and biological activity (2020.07.28 – 2024.07.27)
NCN Miniatura
Dr Adrian Topolski
Surface functionalization of titanium dioxide nanotubes with platinum(II) complexes
Inkubator Innowacyjności UMK 4.0
DSc. Piotr Piszczek, prof. NCU
Production of prototypes of composite materials such as polymer (P) + multi-core oxo-titanium (IV) complex (TOCs) as self-disinfecting systems intended for use in the food industry, trade, public use premises and means of transport
SELECTED PUBLICATIONS
2021
Dzieszkowski, K.; Słotwiński, M.; Rafińska, K.; Muzioł, T.M.; Rafiński Z. NHC-catalyzed enantioselective C2-functionalization of 3-hydroxychromenones via α,β-unsaturated acyl azoliums. Chemical Communications 2021, 57, 9999-10002; Doi: 10.1039/d1cc03708k.
Kuzniak-Glanowska, E.; Konieczny, P.; Pełka, R.; Muzioł, T.M.; Kozieł, M.; Podgajny, R. Engineering of the XY Magnetic Layered System with Adeninium Cations: Monocrystalline Angle-Resolved Studies of Nonlinear Magnetic Susceptibility. Inorganic Chemistry 2020, 60, 10186-10198; Doi: 10.1021/acs.inorgchem.1c00432.
Gąsior, G.; Szczepański, J.; Radtke, A. Biodegradable iron-based materials – what was done and what more can be done? Materials 2021, 14, 3381; Doi: 10.3390/ma14123381.
Kujawa, J.; Al-Gharabli, S.; Muzioł, T.M.; Knozowska, K.; Li, G.; Dumée, L.F.; Kujawski, W. Crystalline porous frameworks as nano-enhancers for membrane liquid separation – recent developments. Coordination Chemistry Reviews 2021, 440, 213969; Doi: 10.1016/j.ccr.2021.213969.
Fandzloch, M.; Jędrzejewski, T.; Dobrzańska, L.; Esteban-Parra, G.M.; Wiśniewska, J.; Paneth, A.; Paneth, P.; Sitkowski, J. New organometallic ruthenium(II) complexes with purine analogs – a wide perspective on their biological application. Dalton Transactions 2021, 50, 5557-5573; Doi: 10.1039/d0dt03974h.
Kubiak, B.; Radtke, A.; Topolski, A.; Wrzeszcz, G.; Golińska, P.; Kaszkowiak, E.; Sobota, M.; Włodarczyk, J.; Stojko, M.; Piszczek, P. The composites of PCL and tetranuclear titanium(Iv)-oxo complexes as materials exhibiting the photocatalytic and the antimicrobial activity. International Journal of Molecular Sciences 2021, 22, 7021; Doi: 10.3390/ijms22137021.
Ehlert, M.; Radtke, A.; Roszek, K.; Jędrzejewski, T.; Piszczek, P. Assessment of titanate nanolayers in terms of their physicochemical and biological properties. Materials 2021, 14, 806: Doi: 10.3390/ma14123381.
Barwiołek, M.; Jankowska, D.; Chorobiński, M.; Kaczmarek-Kędziera, A.; Łakomska, I.; Wojtulewski, S.; Muzioł, T.M. New dinuclear zinc(II) complexes with Schiff bases obtained from o-phenylenediamine and their application as fluorescent materials in spin coating deposition. RSC Advances 2021, 11, 24515-24525; Doi: 10.1039/d1ra03096e.
Kujawa, J.; Al-Gharabli, S.; Wrzeszcz, G.; Knozowska, K.; Lagzdins, R.; Talik, E.; Dziedzic, A.; Loulergue, P.; Szymczyk, A.; Kujawski, W. Physicochemical and magnetic properties of functionalized lanthanide oxides with enhanced hydrophobicity. Applied Surface Science 2021, 542, 148563; Doi: 10.1016/j.apsusc.2020.148563.
2020
Ehlert, M.; Radtke, A.; Jędrzejewski, T.; Roszek, K.; Bartmańsk, M.; Piszczek, P. In vitro studies on nanoporous, nanotubular and nanosponge-like titania coatings, with the use of adipose-erived stem cells. Materials 2020, 13, 1574; Doi: 10.3390/ma13071574.
Ehlert, M.; Radtke, A.; Topolski, A.; Śmigiel, J.; Piszczek, P. The photocatalytic activity of titania coatings produced by electrochemical and chemical oxidation of Ti6A14V substrate, estimated according to ISO 10678:2010. Materials 2020, 13, 2649; Doi: 10.3390/ma13112649.
Fandzloch, M.; Jaromin, A.; Zaremba-Czogalla, M.; Wojtczak, A.; Lewińska, A.; Sitkowski, J.; Wiśniewska, J.; Łakomska, I.; Gubernator, J. Nanoencapsulation of a ruthenium(II) complex with triazolopyrimidine in liposomes as a tool for improving its anticancer activity against melanoma cell lines, Dalton Transactions 2020, 49, 1207-1219; Doi: 10.1039/c9dt03464a.
Topolski, A. Kinetics of chloride substitution in the [Pt2(6NNpy)Cl4] complex by L-methionine. Inorganica Chimica Acta 2020, 506, 119528; Doi: 10.1016/j.ica.2020.119528.
Impert, O.; Kozakiewicz, A.; Wrzeszcz, G.; Katafias, A.; Bieńko, A.; van Eldik, R.; Ozarowski, A. Characterization of a mixed-valence Ru(II)/Ru(III) ion-pair complex. Unexpected high-frequency electron paramagnetic resonance evidence for Ru(III)-Ru(III) dimer coupling. Inorganic Chemistry 2020, 59, 8609-8619; Doi: 10.1021/acs.inorgchem.0c01068.
Nasibipour, M.; Safaei, E.; Wrzeszcz, G.; Wojtczak, A. Tuning of the redox potential and catalytic activity of a new Cu(II) complex by o-iminobenzosemiquinone as an electron-reservoir ligand. New Journal of Chemistry 2020, 44, 4426-4439; Doi: 10.1039/c9nj06396j.
Piszczek, P.; Kubiak, B.; Golińska, P.; Radtke, A. Oxo-titanium(IV) complex/polymer composites – synthesis, spectroscopic characterization and antimicrobial activity test. International Journal of Molecular Sciences 2020, 21, 9663; Doi: 10.3390/ijms21249663.
Piszczek, P.; Radtke, A.; Ehlert, M.; Jędrzejewski, M.; Sznarkowska, A.; Sadowska, B.; Bartmański, M.; Kemal Erdoğan, Y.K.; Ercan, B.; Jedrzejczyk, W. Comprehensive evaluation of the biological properties of surface-modified titanium alloy implants. Journal of Clinical Medicine 2020, 9, 342; Doi: 10.3390/jcm9020342.
Barwiołek, M.; Kaczmarek-Kędziera, A.; Muzioł, T.M.; Jankowska, D.; Jezierska, J.; Bieńko, A. Dinuclear Copper(II) complexes with Schiff bases derived from 2-Hydroxy-5-methylisophthalaldehyde and histamine or 2-(2-Aminoethyl)pyridine and their application as magnetic and fluorescent materials in thin film deposition. International Journal of Molecular Sciences 2020 21, 4587; Doi: 10.3390/ijms21134587.
2019
Ehlert, M.; Roszek, K.; Jędrzejewski, T.; Bartmański, M.; Radtke, A. Titania nanofiber scaffolds with enhanced biointegration activity – preliminary in vitro studies. International Journal of Molecular Science 2019, 20, 5642; Doi: 10.3390/ijms20225642.
Muzioł, T.; Tereba, N.; Podgajny, R.; Kędziera, D.; Wrzeszcz, G. Solvent-assisted structural conversion involving bimetallic complexes based on the tris(oxalato)ferrate(III) unit with the green → blue → red crystal color sequence. Dalton Transactions 2019, 48, 11536-11546: Doi: 10.1039/c9dt02216c.
Radtke, A.; Grodzicka, M.; Ehlert, M.; Jędrzejewski, T.; Wypij, M.; Golińska, P. „To be microbiocidal and not to be cytotoxic at the same time” – silver nanoparticles and their main role on the surface of titania alloy implants. Journal of Clinical Medicine 2019, 8, 334; Doi: 10.3390/jcm8030334.
Richert, M.; Walczyk, M.; Cieślak, M.J.; Kaźmierczak-Barańska, J.; Królewska-Golińska, K.; Wrzeszcz, G.; Muzioł, T.; Biniak, S. Synthesis, X-ray structure, physicochemical properties and anticancer activity of mer and fac Ru(III) triphenylphosphine complexes with a benzothiazole derivative as a co-ligand. Dalton Transactions 2019, 48, 10689-10702; Doi: 10.1039/c9dt03464a.
Janek, M.; Muzioł, T.; Piszczek, P. Trinuclear oxo-titanium clusters – synthesis, structure, and photocatalytic activity. Materials 2019, 12, 3195; Doi: 10.3390/ma12193195.
Tereba, N.; Muzioł, T.; Podgajny, R.;Wrzeszcz, G. Influence of the substituted ethylenediamine ligand on the structure and properties of [Cu(diamine)2Zn(NCS)4].Solv. compounds. Crystals, 2019, 9, 637; Doi: 10.3390/cryst9120637.
Wiśniewska, J.; Fandzloch, M.; Muzioł, T.; Łakomska, I. The hydrolysis of a ruthenium(III) complex with triazolopyrimidine ligands and mechanistic insights into its anticancer activity. Inorganic Chemistry Communications 2019, 109, 107567; Doi: 10.1016/j.inoche.2019.107567.
Liberka, M.; Kobylarczyk, J.; Muzioł, T.; Ohkoshi, S.; Chorąży, S.; Podgajny, R. A heterotrimetallic synthetic approach in versatile functionalization of nanosized (MxCu13-xW7)3+ and (M1Cu8W6) (M = Co, Ni, Mn, Fe) metal-cyanide magnetic clusters. Inorganic Chemistry Frontiers 2019, 6, 3104-3118; Doi: 10.1039/c9qi00898e.
Łakomska, I.; Jakubowski, M.; Barwiołek, M.; Muzioł, T. Different bonding of triazolopyrimidine to platinum(IV) – structural and in vitro cytotoxicity studies. Polyhedron 2019, 160, 123-129; Doi: 10.1016/j.poly.2018.12.022.
Radtke, A. Photocatalytic activity of nanostructured titania films obtained by electrochemical, chemical, and thermal oxidation of Ti6Al4V Alloy – comparative analysis. Catalysts 2019, 9, 279; Doi: 10.3390/catal9030279.
Radtke, A.; Ehlert, M.; Jędrzejewski, T.; Bartmański, M. The morphology, structure, mechanical properties and biocompatibility of nanotubular titania coatings before and after autoclaving process. Journal of Clinical Medicine 2019, 8, 272; Doi: 10.3390/jcm8020272.
Radtke, A.; Ehlert, M.; Jędrzejewski, T.; Sadowska, B.; Więckowska-Szakiel, M.; Holopainen, R.M.; Leskelä, M.; Bartmański, M.; Szkodo, M.; Piszczek, P. Titania nanotubes/hydroxyapatite nanocomposites produced with the use of the atomic layer deposition technique: estimation of bioactivity and nanomechanical properties. Nanomaterials, 2019, 9, 123; Doi: 10.3390/nano9010123.
Wiśniewska, J.; Fandzloch, M.; Łakomska, I. The reduction of ruthenium(III) complexes with triazolopyrimidine ligands by ascorbic acid and mechanistic insight into their action in anticancer therapy. Inorganica Chimica Acta 2019, 484, 305-310; Doi: 10.1016/j.ica.2018.09.051.