Excellence Initiative - Research University
Contactul. Gagarina 7, 87-100 Toruń
tel.: +48 56 611-43-02
fax: +48 56 611-45-26
e-mail: wydzial@chem.umk.pl
obrazek nr 1 obrazek nr 2

Selected publications

 

2021

M. Barwiolek, D. Jankowska, M. Chorobinski, A. Kaczmarek-Kędziera, I. Łakomska, S. Wojtulewski, T. M. Muzioł, “New dinuclear zinc(II) complexes with Schiff bases obtained from o-phenylenediamine and their application as fluorescent materials in spin coating deposition“, RSC Adv., 2021, 11, 24515-24525. IF = 3.36; 100 pkt.

J. Masternak, M. Zienkiewicz-Machnik, I. Łakomska, M. Hodorowicz, K. Kazimierczuk, M. Nosek, A. Majkowska-Młynarczyk, J. Wietrzyk, B. Barszcz, “Synthesis and structure of novel copper(II) complexes with N,O- or N,N-donors as radical scavengers and a functional model of the active sites in metalloenzymes”, Int. J. Mol. Sc., (2021), 22(14)7286 IF = 5.923; 140 pkt.

2020

Iwona Łakomska, Dariusz Śmiłowicz, Mateusz Jakubowski, Jerzy Sitkowski, Andrzej Wojtczak, “Platinum(II) Complexes with Bulky Disubstitute Triazolopyrimidines as Promising Materials for Anticancer Agents”, Materials, (2020),13, 5312. IF = 3.057; 140 pkt.

Mateusz Kowalik, Joanna Masternak, Iwona Łakomska, Katarzyna Kazimierczuk, Anna Zawilak-Pawlik, Piotr Szczepanowski, Oleksiy V. Khavryuchenko, Barbara Barszcz, “Structural Insights into New Bi(III) Coordination Polymers with Pyridine-2,3-Dicarboxylic Acid: Photoluminescence Properties and Anti-Helicobacter pylori Activity”, Int. J. Mol. Sc., (2020), 21,8696. IF = 4.556; 140 pkt.

Joanna Masternak, Agnieszka Gilewska, Barbara Barszcz, Iwona Łakomska, Katarzyna Kazimierczuk, Jerzy Sitkowski, Joanna Wietrzyk, Anna Kamecka, Magdalena Milczarek”Ruthenium(II) and Iridium(III) Complexes as Tested Materials for New Anticancer Agents”, Materials, (2020), 13, 3491. IF = 3.057; 140 pkt.

M. Fandzloch, L. Dobrzańska, T. Jędrzejewski, J. Jezierska, J. Wiśniewska, I. Łakomska,Synthesis, structure and biological evaluation of ruthenium(III) complexes of triazolopyrimidines with anticancer properties”, J. Biol. Inorg. Chem., (2020) 25, 109-124. IF= 3.632; 70 pkt.

M. Fandzloch, A. Jaromin, M. Zaremba-Czogalla, A. Wojtczak, A. Lewińska, J. Sitkowski, J. Wiśniewska, I. Łakomska, J. Gubernator, „Nanoencapsulation of a ruthenium(II) complex with triazolopyrimidine in liposomes as a tool for improving its anticancer activity against melanoma cell lines”, Dalton Trans., (2020), 49, 1207-1219. IF 4.08; 140 pkt.

M. Jakubowski, I. Łakomska, J. Sitkowski, M. Pokrywczyńska, P. Dąbrowski, G. Framski, T. Ostrowski, „Multinuclear magnetic resonance characterization and antiproliferative studies of novel dichlorido platinum(II) complexes containing kinetin riboside and 1-β-D-ribofuranosyl-4-(2-pyridyl)-1H-1,2,3-triazole”, Polyhedron, (2020), 168, 114428. IF=2.067; 100pkt.

2019

J. Wiśniewska, M. Fandzloch, T. Muzioł, I. Łakomska, „The hydrolysis of a ruthenium (III) complex with triazolopyrimidine ligands and mechanistic insights into its anticancer activity”, Inorg. Chem. Comm., (2019) 109, 107567.

J. Wiśniewska, M. Fandzloch, I. Łakomska, “The reduction of ruthenium(III) complexes with triazolopyrimidine ligands by ascorbic acid and mechanistic insight into their action in anticancer therapy“, Inorganica Chimica Acta, (2019), 484, 305-310.

I. Łakomska, M. Jakubowski, M. Barwiołek, T. Muzioł, “Different bonding triazolopyrimidine to platinum(IV). Structural and in vitro cytotoxicity studies”, Polyhedron, (2019), 160, 123-129.

2018

M.Jakubowski, I. Łakomska, J. Sitkowski, J. Wiśniewska, “Dicarboxylato platinum(II) complexes containing dimethyl sulfoxide and trazolopyrimidine as potential anticancer agents: synthesis, structural and biological studies in solution”, New J. Chem., (2018), 42, 8113-8122.

M. Fandzloch, L. Dobrzańska, J. Jezierska, B. Filip-Psurska, J. Wiśniewska, J. Wietrzyk, J. M. Salas, I. Łakomska „In search of new anticancer drug – dimethylsulfoxide ruthenium(III) complex with triazolopyrimidine derivative and preliminary studies towards understanding the mode of action”, Polyhedron (2018), 141, 239–246.

2017

M. Fandzloch, J.M. Mendez Arriaga, M. Sanchez-Moreno, A. Wojtczak, J. Jezierska, J. Sitkowski, J. Wiśniewska, J.M. Salas, I. Łakomska „Strategies for overcoming tropical disease by ruthenium complexes with purine analog: Application against Leishmania spp. and Trypanosoma cruzi”, J. Inorg. Biochem., (2017), 176, 144-155.

M. Barwiołek, M. Babinska, A. Kozakiewicz, A. Wojtczak, A. Kaczmarek-Kedziera, E. Szłyk, “New fluorescent [Ag(I)(Schiff base)] complexes derived from 9-anthracenecarboxaldehyde and their application in thin layers deposition”, Polyhedron (2017), DOI: 10.1016/j.poly.2017.06.019

Iwona Łakomska, Magdalena Babinska, Andrzej Wojtczak, Anna Kozakiewicz, Jerzy Sitkowski, Andrzej A. Jarzęcki, “Experimental and theoretical investigation of the complexation of 5-methyl-7-isobutyl-1,2,4-triazolo[1,5-a]pyrimidine by platinum(II) ion”, New J. Chem., (2017), 41, 7775-7782

K. Hoffmann, J. Wiśniewska, A. Wojtczak, J. Sitkowski, A. Denslow, J. Wietrzyk, M. Jakubowski, I. Łakomska, “Rational design of dicarboxylato platinum(II) complexes with purine-mimetic ligands as novel anticancer agents”, J. Inorg. Biochem., (2017), 172, 34-45

2016

I. Łakomska, M. Babinska, A. Wojtczak, J. Sitkowski, “Synthesis, characterization and in vitro cytotoxicity of three types of platinum(II) complexes containing 5,7-diethyl-1,2,4-triazolo[1,5-a]pyrimidine”, Inorg. Chim. Acta, (2016), 453, 516-521

I. Łakomska, M. Fandzloch, “Application of 1,2,4-triazolo[1,5-a]pyrimidines for the design of coordination compounds with interesting structures and new biological properties”, Coord. Chem. Rev., (2016), 327-328, 221-241

M. Fandzloch, A. Wojtczak, J. Wiśniewska, K. Stefańczak, J. M. Salas, I. Łakomska, “Ruthenium(III) complexes with monodentate 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one: structural characterization, interaction with DNA and proteins”, Inorg. Chim. Acta, (2016), 443, 170-178

I. Łakomska, K. Stefańczak, M. Fandzloch, J. Sitkowski, B. Filip-Psurska, A. Wojtczak, “Use of 1,2,4-triazolo[1,5-a]pyrimidines to design new “piano-stool” ruthenium(II) compounds” Polyhedron, (2016), 109, 33-39

2015

K. Hoffmann, I Łakomska, J. Wiśniewska, A. Kaczmarek-Kędziera, J. Wietrzyk, “Acetate platinum(II) compound with 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine that overcome cisplatin resistance: structural characterization, in vitro cytotoxicity and kinetic studies”, J. Coord. Chem., (2015), 68(17-18), 3193–3208

M. Nowacki, M. Wiśniewski, K.M. Werengowska-Ciećwierz, K. Roszek, J. Czarnecka, I. Łakomska, T. Kloskowski, D. Tyloch, R. Dębski, K. Pietkun, M. Pokrywczyńska, D. Grzanka, R. Czajkowski, G. Drewa, A. Jundziłł, J.K. Agyin, S.L. Habib, A.P. Terzyk, T. Drewa, „Nanovehicles as a novel target strategy for hyperthermic intraperitoneal chemotherapy: a multidisciplinary study of peritoneal carcinomatosis”, Oncotarget, (2015), 6(26), 22776-22798

A.W. Augustyniak, M. Fandzloch, M. Domingo, I. Łakomska, J.A.R. Navarro, „A vanadium(IV) pyrazolate metal–organic polyhedron with permanent porosity and adsorption selectivity”, Chem. Comm., (2015), 51, 14724-14727

J. G. Małecki, I. Łakomska, A. Maroń, M. Szala, M. Fandzloch, J. E. Nycz, „Phosphorescent emissions of phosphine copper(I) complexes bearing 8-hydroxyquinoline carboxylic acid analogue ligands”, J. Lumin., (2015); 161, 382-388

2014

I. Łakomska, M. Fandzloch, A. Wojtczak, „Dimeric ruthenium-triazolopyrimidine complex: Synthesis and structural characterization”, Inorg. Chem.Commun., (2014), (2014), 49, 24–26

I. Łakomska, K. Hoffmann, A. Wojtczak, J. Sitkowski, E. Maj, J. Wietrzyk, „Cytotoxic malonate platinum(II) complexes with 1,2,4-triazolo[1,5-a]pyrimidine derivatives: structural characterization and mechanism of the suppression of tumor cell growth”, J. Inorg. Biochem., (2014); 141, 188-197

M. Fandzloch, A. Wojtczak, J. Sitkowski, I. Łakomska, „Interaction of ruthenium(II) and ruthenium(III) ions with 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one”, Polyhedron, (2014); 67, 410-415

I. Łakomska, K. Hoffmann, T. Muzioł, J. Sitkowski, „Multinuclear magnetic resonance and X-ray characterization of platinum(II) complexes with substituted-1,2,4-triazolo [1,5-a]pyrimidines”, J. Mol. Struct., (2014), 1056-1057, 146-151

2013

I. Łakomska, M. Fandzloch, T. Muzioł, T. Lis, J. Jezierska, „Synthesis, characterization and antitumor properties of two highly cytotoxic ruthenium(III) complexes with bulky triazolopyrimidine ligands”, Dalton Trans., (2013), 42, 6219 – 6226

2012

I. Łakomska, K. Hoffmann, J. Sitkowski, „Significant in vitro cytotoxicity of hexafluoroglutarate platinum(II) coordination compound with 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine”, Acta of the International Symposia on Metal Complexes, (2012), v.2, 338-339

M. Fandzloch, I. Łakomska, T. Muzioł. T. Lis, J. Jezierska, „Promising, highly cytotoxic ruthenium-based complexes with bulky triazolopyrimidine ligand: synthesis, structural characterization and antiproliferative activity in vitro”, The Acta of the International Symposia on Metal Complexes, (2012), v.2, 336-337

I. Łakomska, M. Fandzloch, T. Muzioł, J. Sitkowski, J. Wietrzyk, „Structure-cytotoxicity relationship for different types of mononuclear platinum(II) complexes with 5,7-ditertbutyl-1,2,4-triazolo[1,5-a]pyrimidine”, J. Inorg. Biochem., (2012), 115, 100-105

M. Fandzloch, I. Łakomska, A. Szydłowska-Czerniak, G. Karlovits, „Comparison of cytotoxic in vitro properties of rapeseed with inorganic chemotherapeutic. Oilseed Crops”, (2012), 191-193. ISBN 978-83-61607-79-3

I. Łakomska, M. Fandzloch, B. Popławska, J. Sitkowski, „Platinum(II) complexes with 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines: spectroscopical characterization and cytotoxic activity in vitro”, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, (2012), 91, 126-129

I. Łakomska, K. Hoffmann, A. Topolski, T. Kloskowski, T. Drewa, „Spectroscopic, kinetic and cytotoxic in vitro study of hexafluoroglutarate platinum(II) complex with 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine”, Inorg. Chim. Acta, (2012); 387, 455-459